Colon Cancer survival increases with vitamin D, up to 50 ng – Aug 2024

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Serum 25-Hydroxyvitamin D and Five-Year Survival in Primary Colon Cancer: A Retrospective Cohort Study

Nutr Cancer. 2024 Aug 9:1-10. doi: 10.1080/01635581.2024.2389580
Raphael E Cuomo 1

This study examined the link between serum 25-hydroxyvitamin D (25(OH)D) and mortality in patients with colon cancer. Using a clinical database from the University of California, serum 25(OH)D measures were averaged for the time following diagnosis until either the time of death or 5 years had elapsed. Analytical methods included the use of Generalized Additive Models (GAM), logistic regression, and Cox proportional hazards models to examine non-linear relationships and the impact of 25(OH)D on 5-year mortality. This study assessed 1,602 patients with colon cancer having a median 25(OH)D of 31.8 ng/mL and a 5-year mortality rate of 22.7%.
A significant association between higher post-diagnosis vitamin D levels and decreased 5-year mortality was observed. This association persisted after adjusting for disease severity and significant demographic confounders, in both a logistic regression model for 5-year mortality (OR = 0.79, 95% CI: 0.66-0.92, p < 0.001) and a cox proportional hazards model for survival (HR = 0.94, CI: 0.88-0.99, p = 0.048).
GAM illustrated a steep increase in survival probability up to a plateau, suggesting a threshold effect beyond roughly 50.0 ng/mL. This study found a potential protective role of vitamin D in the survival of colon cancer patients, supporting the correction of levels below 25 ng/mL but ideally above 50 ng/mL.

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VitaminDWiki – Cancer - Colon category contains:

• Cancer - Colon category listing has 145 items

• 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
• 25+ Colon Cancer meta-analyses
• Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
• Cancer - After diagnosis category listing has 113 items along with related searches
• see also:
  Overview Cancer-Colon and vitamin D.   Overview Cancer and vitamin D  Overview Gut and vitamin D   Cancer and Vitamin D - many studies

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VitaminDWiki - Is 50 ng of vitamin D too high, just right, or not enough contains

Vitamin D	Treats
150 ng	Multiple Sclerosis *
80 ng	Cluster Headache * Reduced office visits by 4X *
70 ng	Sleep *
60 ng	Breast Cancer death reduced 60% Preeclampsia RCT
50 ng	COVID-19 T1 Diabetes Fertility Psoriasis Infections Review Infection after surgery
40 ng	Breast Cancer 65% lower risk Depression ACL recovery Hypertension Asthma?
30 ng	Rickets

* Evolution of experiments with patients, often also need co-factors

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COVID fought by 50 ng of Vitamin D

• Is 50 ng of Vitamin D enough to fight COVID - TrialSiteNews - Jan 2024
• COVID etc. prevented and treated with 50,000 IU Vitamin D capsules - July 2022
• Discussion of COVID and 50 ng of Vitamin D (video and transcript)– Dr. Campbell Nov 17, 2021
• COVID probably fought by Vitamin D, might need 50 ng - Dr. Patrick Nov 8, 2021
• COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
• Vitamin D and COVID, review of evidence, loading dose if less than 50 ng - Masterjohn Sept 2021
• T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021
• COVID-19 prognostic indicators in plasma extrapolate to zero if Vitamin D is 40 to 80 ng – March 2021
• To protect against COVID-19, how much vitamin D – 20 to 50 ng – March 19, 2021